1L6-Hydroxymethyl-chiro-inositol-2-(R)-2-O-methyl-3-O-octadecyl-sn-glycerocarbonate White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A phosphatidylinositol ether analog that potently and selectively inhibits Akt (PKB) (IC50 of 5.0 µM). Moderately inhibits PI 3-K activity (IC50 = 83.0 µM). Also inhibits the growth of various cancer cell lines with IC50 values in the 1 - 10 µM range. Purity: ≥95% by TLC. Ref.: Hu, Y., et al. 2000 J. Med. Chem. 43, 3045. |