H-YGRKKRRQRRR-AVTDHPDRLWAWEKF-OH
TAT-TCL110-24 White solid. Supplied as an acetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable version of the Akt Inhibitor VI, Akt-in (Cat. No. 124013) fused with the protein transduction domain TAT that displays antitumor properties. Inhibits the phosphorylation of Akt selectively in HEK 293 and QRsP-11 fibrosarcoma cells stimulated with PDGF (complete inhibition at ~ 50 µM) with minimal inhibition towards PKA, PKC, PDK1, p42/44 MAPK, or p38 MAPK. Shown to prevent the proliferation of T4 cells, and tumor growth in syngeneic C57BL/6 mice. Purity: ≥95% by HPLC. H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Ala-Val-Thr-Asp-His-Pro-Asp-Arg-Leu-Trp-Ala-Trp-Glu-Lys-Phe-OH Ref.: Hiromura, M., et al. 2004. J. Biol. Chem. 279, 53407. | 
