9-Methoxy-2-methylellipticinium acetate
MMEA
NSC 627505

Orange red solid. PROTECT FROM LIGHT. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable ellipticine compound that potently and selectively induces apoptosis in human endometrial cancer cells (RL95-2 and Ishikawa) that exhibit elevated Akt activity (effective concentration = 12-24 µM), but not on cells with low Akt activity. Directly affects the activity by Akt, but not the level of cellular phosphorylation of Akt, ERK1/2, JNK1/2, PDK1, PKC isoforms, or serum and glucocorticoid-inducible kinase (SGK). Purity: ≥95% by HPLC. CAS 98510-80-6.

Ref.: Jin, X., et al. 2004. Br. J. Cancer 91, 1808.