9-Nitro-7,12-dihydroindolo[3,2-d][1]benzazepin-6(5H)-one
9-Nitropaullone
NSC 705701 Brown solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent inhibitor of GSK-3b (IC50 = 4 nM) and Cdk1/cyclin B (IC50 = 35 nM). Displays remarkable in vitro antitumor activity. Inhibits Tau phosphorylation at sites that are typically phosphorylated by GSK-3b in Alzheimer’s disease. Also inhibits Cdk5/p25-dependent phosphorylation of DARPP-32. Purity: ≥95% by HPLC. CAS 237430-03-4. Ref.: Leost, M., et al. 2000. Eur. J. Biochem. 267, 5983. Schultz, C., et al. 1999. J. Med. Chem. 42, 2909. |
