3-(6-Oxo-9-nitro-5,6,7,12-tetrahydroindolo[3,2-d][1]benzazepin-2-yl)propionitrile Light orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. An Alsterpaullone (Cat. No. 126870) derivative that acts as a highly potent, ATP-competitive, selective inhibitor of Cdk1/cyclin B and GSK-3b (IC50 = 230 pM and 800 pM, respectively; [ATP] = 15 µM). Displays ~37-fold greater selectivity for Cdk1/cyclin B over Cdk5/p25 (IC50 = 30 nM). Shown to inhibit other kinases in a commercially available testing screen panel (pIC50 = −logIC50[M]; pIC50 ~ 7.5, 7.0, 7.0, 6.5, 6.5, 6.0, and 6.0 for Cdk2/A, Cdk4/D1, GSK-3b, PDGFRb, Src, VEGFR-2, and VEGFR-3, respectively; [ATP] = 1 µM). Purity: ≥90% by HPLC. CAS 852529-97-0. Ref.: Kunick, C., et al. 2005. ChemBioChem. 6, 541. |
