Allopregnan-3a-ol-20-one
3a-Hydroxy-5a-pregnan-20-one
3a-OH-DHP White solid. A natural metabolite of progesterone that is devoid of any progestational activity. Acts as a potent ligand of GABA type A receptor complexes in the CNS. Potentiates the GABA receptor-mediated chloride uptake in synaptosomes 100- to 1,000-fold more effectively than benzodiazepines or barbiturates. Causes a rapid increase in Ca2+ influx in a dose-dependent manner (EC50 =10 nM in fetal hypothalamic neurons). Purity: ≥95% by HPLC. RTECS TU4383000, CAS 516-54-1. Merck Index: 14, 275
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