Off-white to yellow solid. PROTECT FROM LIGHT. HYGROSCOPIC. An inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na⁺ entry and Na⁺,K⁺-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na⁺/H⁺ exchange pathway. Purity: ≥98% by HPLC. RTECS UQ2275500, CAS 2016-88-8.

Merck Index: 14, 406
Ref.: Knoll, A., et al. 1999. Microvasc. Res. 58, 1. Swiercz, R., et al. 1999. Oncol. Rep. 6, 523. Moran, A., et al. 1995. Am. J. Physiol. 268, C350. Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245. Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215. Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101. Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
R: 25; S: 45-36