7-AAD
7-Amino-AMD
7-Aminoactinomycin C1
7-Aminodactinomycin Reddish-purple solid. PROTECT FROM LIGHT. HYGROSCOPIC. 7-Aminoactinomycin D, like its parent molecule, actinomycin D, is a DNA intercalator and has antibacterial properties. Exhibits growth-inhibitory activity against certain leukemias and sarcomas. Fluorescent excitation and emission maxima are 500 and 672 nm, respectively. Complexes with DNA and absorbs at 555 nm and emits at 655 nm. Useful in distinguishing early apoptotic cells, which have lost membrane integrity, from apoptotic and live cells. Has been used in DNA analysis and as a probe for chromosome structure and function. Purity: ≥85% by HPLC. RTECS AU1579000, CAS 7240-37-1. Merck Index: 14, 2800
Ref.: Schmid, I., et al. 1994. J. Immunol. Methods 170, 145. Berg, R.J., et al. 1993. Carcinogenesis 14, 103. Chen, F.M. 1992. Biochemistry 31, 6223. Schmid, I., et al. 1992. Cytometry 13, 204. Toba, K., et al. 1992. Cytometry 13, 60. Sengupta, S.K., et al. 1975. J. Med. Chem. 18, 1175.
R: 28; S: 36/37-45-28 |
