281D
6-Phenylimidazo[2,1-b]-1,3,4-thiadiazole-2-sulfonamide

Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable imidazothiadiazole compound that activates cellular transcription factor HSF1 by binding to HSP90 and disrupting its association with HSF1. Shown to induce HSF1-dependent expression of HSP70 and HSP25 and effectively block NRAGE- and p75NTR-mediated JNK activation and apoptosis in PC12 cells in a dose-dependent manner (>90% inhibition at 40 µM). Purity: ≥98% by HPLC. CAS 63735-71-7.

Ref.: Salehi, A.H., et al. 2006. Chem. Biol. 13, 213.