4-Amino-1,8-naphthalimide Orange amorphous solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, cell-permeable poly(ADP-ribose) polymerase (PARP) inhibitor (IC50= 180 nM in vitro) and radiation sensitizer. Reduces ischemia-reperfusion injury in the heart and skeletal muscle. Purity: ≥95% by HPLC. RTECS DE4081000, CAS 1742-95-6. Ref.: Schlicker, A., et al. 1999. Int. J. Radiat. Biol. 75, 91. Bowes, J., and Thiemermann, C. 1998. Br. J. Pharmacol. 124, 1254. Thiememann, C., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 679. Radons, J., et al. 1996. Biochem. Biophys. Res. Commun. 199, 1270. Thiemermann, C., et al. 1996. Proc. Natl. Acad. Sci. USA 94, 679. Banasik, M., et al. 1992. J. Biol. Chem. 267, 1569.
R: 36/37/38; S: 26-37/39 |
