AA
2-Hydroxy-6-pentadecylbenzoic Acid
6-Pentadecylsalicylic Acid White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable salicylic acid analog that acts as a potent, non-competitive inhibitor of p300 and PCAF (p300/CBP-associated factor) histone acetyltransferase activities (HAT; IC50 ~8.5 µM and ~5 µM, respectively). Shown to affect HAT-dependent transcription from a chromatin template, but does not affect DNA transcription. Also reported to display a variety of biological activities, such as antibacterial, and antimicrobial action; and inhibition of prostaglandin synthase, tyrosinase, and lipoxygenase. Selectively enhances the activity of Aurora A. Purity: ≥95% by HPLC. CAS 16611-84-0. Ref.: Kishore, A.H. 2008. J. Med. Chem. 51, 792. Balasubramanyam, K., et al. 2003. J. Biol. Chem. 278, 19134. Paramashivappa, R., et al. 2002. J. Agric. Food Chem. 50, 7709. |
