(Z,E)-3-(Imidazol-4-ylmethylene)indolin-2-one Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable indolinone compound that displays anti-angiogenesis properties (30% inhibition of control at 10 µM in an in vitro rat aortic ring model ) with a potency that is comparable to that of SU5416 (Cat. No. 676487; 22% inhibition of control at 10 µM). Acts as a moderate ATP-competitive inhibitor of hEGF-R tyrosine kinase activity (54% inhibition at 10 µM). Purity: ≥95% by HPLC. Ref.: Braud, E., et al. 2003. J. Enzyme Inhib. Med. Chem. 18, 243. | 
