K1-3 rHuAng K1-3 Lyophilized. Lyophilized from 0.5X PBS. A proteolytic fragment containing the first three kringle structures of plasminogen. Acts as a specific inhibitor of endothelial cell growth and angiogenesis. Displays increased inhibitory activity (ED50 = 70 nM) relative to kringles 1 - 4 (ED50 = 135 nM). Purity: ≥95% by HPLC and SDS-PAGE. Contaminants: Endotoxins: ≤ 0.1 ng/µg protein. Ref.: Cao, R., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 5728. Cao, E., et al. 1997. J. Biol. Chem. 272, 22924. Sim, B.K., et al. 1997. Cancer Res. 57, 1329. Wu, Z., et al. 1997. Biochem. Biophys. Res. Commun. 236, 651. O'Rieilly, M.S., et al. 1994. Cell 79, 315. Peterson, T.E., et al. 1990. J. Biol. Chem. 265, 6104. Forsgren, M., et al. 1987. FEBS Lett. 213, 254. Malinowski, D.P., et al. 1984. Biochemistry 23, 4243. |