2-(p-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate

White solid. Strongly activates stress-activated protein kinases (JNK/SAPK) and p38 MAP kinase in mammalian cells. Synergizes with growth factors to induce c-fos and c-jun by acting as a potent signaling agonist. An inhibitor of protein synthesis at the translation step. Also known to induce apoptosis in the human monoblastoid cell line, U937. Purity: ≥98% by TLC. RTECS BZ9800000, CAS 22862-76-6.

Merck Index: 14, 670
Ref.: Hazzalin, C.A., et al. 1998. Mol. Cell. Biol. 18, 1844. Kardalinou, E., et al. 1994. Mol. Cell. Biol. 14, 1066. Kyriakis, J.M., et al. 1994. Nature 369, 156. Sanchez, I., et al. 1994. Nature 372, 794. Shinohara, K., and Oka, T. 1994. NeuroReport 5, 2201. Kochi, S. K., and Collier, R.J. 1993. Exp. Cell Res. 208, 296.
R: 23/24/25; S: 36/37/39-45