ASMP-3 Lyophilized. PROTECT FROM LIGHT. A macrocyclic ansa macrolide that inhibits mammalian brain tubulin assembly. Reported to competitively bind to Asn100 site of fungal and brain tubulins. A potent anti-mitotic agent that inhibits vinblastine-induced spiral formation. Shows potent cytotoxicity against the human solid tumor cell lines A-549 and HT-29. Purity: ≥95% by TLC. RTECS OQ2293000, CAS 66584-72-3. Ref.: Iwasaki, S. 1998. Bioconjug. Chem. 4, 284. Li, Y., et al. 1992. Biochem. Biophys. Res. Commun. 187, 722. Correia, J.J. 1991. Pharmacol. Ther. 52, 127. Sullivan, A.S., et al. 1990. Cancer Res. 50, 4277. Suwanborirux, K., et al. 1990. Experientia 46, 117.
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