Anthrax LF Protease Inhibitor
Bacillus anthracis LF Protease Inhibitor
In-2-LF White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable N-acetylated, C-hydroxamate derivative of a 14-mer peptide designed from the MEK-2 template that acts as a competitive inhibitor of Anthrax lethal factor (LF) metalloprotease (Ki = 1 nM). Also inhibits MEK-3 cleavage. Protects against Anthrax toxin induced cytotoxicity in RAW264.7 and J772.A1 cells. Purity: ≥97% by HPLC. Ac-Gly-Tyr-bAla-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Val-Leu-Arg-NHOH Ref.: Peinado, J.R., et al. 2004. Biochem. Biophys. Res. Commun. 321, 601. Tonello, F., et. al. 2002. Nature 418, 386. | 
