4′,5,7-Trihydroxyflavone Yellow crystalline solid. Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G2/M arrest and induces morphological differentiation. Purity: Single spot by TLC. RTECS LK9276000, CAS 520-36-5. Merck Index: 14, 730
Ref.: Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun. 212, 767. Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325. Kuo, M.L., et al. 1994. Cancer Lett. 87, 91. Sato, F., et al. 1994. Biochem. Biophys. Res. Commun. 204, 578.
R: 36/37/38; S: 36-26 |
