Acetovanillone 4-Hydroxy-3-methoxyacetophenone Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, anti-inflammatory phenolic compound that acts as a potent and selective inhibitor of NADPH oxidase. Shown to block peroxynitrite formation in murine macrophages. Reported to increase glutathione synthesis through activation of AP-1. Also reported to prevent phagocytosis of myelin by macrophages (10 mM). Purity: ≥98% by GC. RTECS AM8800000, CAS 498-02-2. Merck Index: 14, 741 Ref.: Abid, M.R., et al. 2000. FEBS Lett. 486, 252. Muijsers, R.B., et al. 2000. Br. J. Pharmacol. 130, 932. Lapperre, T.S., et al. 1999. FEBS Lett. 443, 235. Supinski, G., et al. 1999, J. Appl. Physiol. 87, 776. van der Goes, A., et al. 1998. J. Neuroimmunol. 92, 67. Hart, B.A., and Simmons, J.M. 1992. Biotechnol. Ther. 3, 3. |