Apo B
Apo B-100 Solid. Lyophilized from 50 mM Na2CO3, 50 mM NaCl, 10 mM sodium deoxycholate, pH 10.0. Native apolipoprotein B from human plasma. Produced by the liver, and is a dominant protein constituent of LDL that is also present in VLDL. Ligand for LDL receptor, directing clearance of LDL from plasma to the liver. Functions as a cofactor in enzymatic reactions. Mean serum concentration: 950 µg/ml. Higher levels are reported in familial hyperlipidemia, obesity, and diabetes. Purity: ≥95% by SDS-PAGE. Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. Ref.: Jiang, X.C., et al. 2001. Nat. Med. 1, 847. Zhou, M., et al. 1995. J. Biol. Chem. 270, 25220. Sivaram, P., et al. 1993. J. Biol. Chem. 269, 9409. Sato, R., et al. 1990. J. Biol. Chem. 265, 11880. |
