Apo C-II Lyophilized. Lyophilized from 10 mM NH4HCO3, pH 7.4. Native apolipoprotein C-II from human plasma. Found primarily in VLDL and chylomicrons. Functions as a cofactor for lipoprotein lipase. Elevated serum levels of Apo C-II are common in type I, III, IV, and V hyperlipoproteinemia. Low serum concentrations of Apo C-II are indicative of nephrotic syndrome (Tangier’s Disease). Purity: ≥95% by SDS-PAGE. Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV. Ref.: Brunzell, J.D. 1989. in The Metabolic Basis of Inherited Disease, 6th Edition (Scriver, G.R., ed.) p. 1165, McGraw Hill, New York. Le, N.A., et al. 1988. J. Lipid Res. 29, 669. Jackson, R.L., and Holdsworth, G. 1986. Methods Enzymol. 128, Chapter 14. |
