rhApo E4 Liquid. In 700 mM NH4HCO3. AVOID FREEZE/THAW CYCLES. Recombinant, human apolipoprotein E-E4 (arginine at amino acid 112 and 158) expressed in S. frugiperda insect cells using a baculovirus expression system. Binds to the LDL receptor, and binds to b-amyloid protein with higher affinity than Apo E2 and E3. Significantly higher levels of E4 are reported in patients with Alzheimer’s Disease and atherosclerosis. Promotes early appearance of b-amyloid and neurofibrillary tangles in the elderly. Purity: ≥95% by SDS-PAGE. Ref.: Warzok, R.W., et al. 1998. Alzheimer Dis. Assoc. Disord. 12, 33. Corder, E.H., et al. 1993. Science 261, 921. Strittmatter, W.J., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 8098. Gretsch, D.G., et al. 1991. Proc. Natl. Acad. Sci. USA 88, 8530. Rall, S.C, et al. 1986. Methods Enzymol. 128, 273.
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