PETCM
a-(Trichloromethyl)-4-pyridineethanol Beige solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable pyridyl compound that selectively promotes apoptosome formation and the subsequent caspase activation by antagonizing prothymosin-a (ProT), a negative regulator of mitochondria-initiated caspase activation. Shown to elevate caspase-3 activity in cancer cell extracts in a dose-dependent manner (maximum stimulation at ~ 100 to 200 µM in HeLa cell lysate). Purity: ≥98% by HPLC. Ref.: Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533. Jiang, X., et al. 2003. Science 299, 223. Nicholson, D.W., and Thornberry, N.A. 2003. Science 299, 214. |
