1-(3,4-Dichlorobenzyl)-1H-indole-2,3-dione Orange solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable indoledione compound that activates caspases in a cytochrome c-dependent manner and induces apoptosis in tumor cells by promoting the oligomerization of Apaf-1 into the mature apoptosome. Its cytotoxicity is selective towards tumor cells (IC50 < 10 µM for Jurkat, Molt-4, and CCRF-CEM) and shows little or no effect on non-tumor cells or cells that are deficient in caspase-3 or Apaf-1. Purity: ≥95% by HPLC. CAS 79183-19-0. Ref.: Nguyen, J.T., and Wells, J.A. 2003. Proc. Natl. Acad. Sci. USA 100, 7533. |
