NS3694

White solid. PROTECT FROM LIGHT. A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-a-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases. Purity: ≥98% by HPLC. CAS 426834-38-0.

Ref.: Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.