Apoptolidin, Nocardiopsis sp. White lyophilized solid. PROTECT FROM LIGHT. PROTECT FROM MOISTURE. PACKAGED UNDER INERT GAS. A cell-permeable macrolide antibiotic that induces apoptosis in E1A-transformed cells (IC50 = 11 ng/ml) with high selectivity. Although the apoptotic activity of apoptolidin correlates with its F0F1-ATPase inhibition (IC50 = 700 nM in yeast), the basis of the cancer selectivity is still not fully understood. Apoptolidin quickly isomerizes to and co-exists with Isoapoptolidin (Cat. No. 371959) in equilibrium (k1 = 0.0656 h-1 and Keq = 0.616 in Dulbecco's PBS at 37°C). Purity: ≥95% by HPLC. CAS 194874-06-1. Ref.: Daniel, P.T., et al. 2006. Angew. Chem. Int. Ed. Engl. 45, 872. Wender, P.A., et al. 2002. Org. Lett. 4, 3819. Salomon, A.R., et al. 2001. Chem. Biol. 8, 71. Salomon, A.R., et al. Proc. Natl. Acad. Sci. USA 97, 14766. Kim, J.W., et al. 1997. J. Antibiot. 50, 628. |
