20:4 cis,cis,cis,cis-5,8,11,14-Eicosatetraenoic Acid Colorless oil. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Precursor for prostaglandins, prostacyclin, and thromboxane. Binds to G-protein a-subunits in a covalent, post-translational manner. Inhibits Ras-GAP. Stimulates the synthesis of nitric oxide by platelets. Modulates nitric oxide production by prostaglandin synthesis via the cyclooxygenase pathway. Purity: ≥99% by TLC and GC. RTECS CE6675000, CAS 506-32-1. Merck Index: 14, 765 Ref.: Hallak, H., et al. 1994. J. Biol. Chem. 269, 4713. Khurana, G., and Bennett, M.R. 1993. Br. J. Pharmacol. 109, 480. Han, J.-W., et al. 1991. Science 252, 576. Radomski, M.W., et al. 1990. Br. J. Pharmacol. 101, 325. Neddleman P., et al. 1986. Annu. Rev. Biochem. 55, 69. R: 20/21/22-36/37/38; S: 36-26 |