2-AG Colorless oil. In acetonitrile. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A putative endogenous ligand for cannabinoid receptors that competitively binds to both CB1 and CB2. Induces Ca2+ transients in NG108-15 cells expressing CB1 receptor and HL-60 cells exhibiting CB2 receptor. Exhibits potent antiproliferative activity on EFM-19 human breast cancer cells (IC50 = 0.5 - 1.0 µM). Purity: >96% by TLC. CAS 53847-30-6. Ref.: Sugiura, T., and Waku, K. 2000. Chem. Phys. Lipids 108, 89. De Petrocellis, L., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 8375. Ouyang, Y., et al. 1998. Mol. Pharmacol. 53, 676. Sugiura, T., et al. 1998. Biochem. Biophys. Res. Commun. 243, 838. Stella, N., et al. 1997. Nature 388, 773.
R: 11-23/24/25; S: 16-27-45 |
