AA-5-HT
N-Arachidonyl-5-hydroxytryptamine Liquid. In methyl acetate. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A novel synthetic arachidonic acid derivative that potently inhibits anandamide hydrolysis in both cell-free preparations and intact cells without affecting anandamide uptake. Acts as a weak ligand of CB1 receptors in in vitro binding assays. Behaves as a tight-binding, albeit non-covalent, competitive, and mixed inhibitor of fatty acid amide hydrolase (IC50 = 12 µM in mouse neuroblastoma N18TG2 cells). Does not significantly interfere with cPLA2 in intact cells. Irreversibly inactivates soybean 15-lipoxygenase (Ki ~ 20 µM). Purity: ≥90% by TLC. Ref.: Bisogno, T., et al. 1998. Biochem. Biophys. Res. Commun. 248, 515.
R: 11; S: 7-16 | 
