RGDFV Peptide, Cyclic White solid. Supplied as a trifluoroacetate salt HYGROSCOPIC. Potent inhibitor of cell adhesion. Inhibits tumor cell adhesion to laminin and vitronectin substrates. In vivo investigations in rats showed it to be useful in the amelioration of ischemic acute renal failure in rats. Also inhibits tubular obstruction by preventing cell-cell adhesion. Inhibits the redistribution of c-Src into focal adhesions, thereby leading to impaired MAP Kinase activation. Purity: ≥95% by HPLC. CAS 137813-35-5. Ref.: Shono, T., et al. 2001. Exp. Cell Res. 268, 169. Matsuno, H., et al. 1994. Circulation 90, 2203. Noiri, E., et al. 1994. Kidney Int. 46, 1050. Gurrath, M., et al. 1992. Eur. J. Biochem. 210, 911. |
