4-(Imidazolylmethyl)-1-nitro-9H-9-xanthenone White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent, competitive, nonsteroidal inhibitor of aromatase (P450arom; IC50 = 40 nM for human aromatase). Reported to be more potent than fadrozole in inhibiting aromatase activity. Does not significantly inhibit 17a-hydroxylase. Purity: ≥95% by HPLC. Ref.: Recanatini, M., et al. 2001. J. Med. Chem. 44, 672. |