FR-900520
Immunomycin

White crystalline solid. An ethyl analog of FK506 with similar immunosuppressant properties. Acts by binding to immunophilins. Inhibits the synthesis of Th-1 and Th-2 type cytokines in target cells. Biological activity: Fully active via yeast rotamase (FK 506 binding protein) inhibition. Purity: ≥90% by HPLC. RTECS CI7570000, CAS 11011-38-4.

Ref.: Paul, C., et al. 2000. Expert Opin. Invest. Drugs 9, 69. Kawai, M., et al. 1993. FEBS Lett. 316, 107. Pilot-Matias, T.J., et al. 1993. Gene 128, 219. Shafiee, A., et al. 1993. J. Antibiot. 46, 1397. Petros, A.M., et al. 1992. J. Med. Chem. 35, 2467.
R: 20/21/22-36/37/38; S: 26-36