Cyclopropanecarboxylic acid-(3-(4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino)-phenyl)-amide White solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively). Purity: ≥98% by HPLC. CAS 879127-16-9. Ref.: Zhang, Q., et al. 2006. J. Am. Chem. Soc. 128, 2182. |
