A3K/V10F-AIP
AIP-II
KKKLRRQEAFDAL White lyophilized solid. Supplied as a trifluoroacetate salt. HYGROSCOPIC. PACKAGED UNDER INERT GAS. An AIP (Cat. No. 189480) analog, in which Ala3 and Val10 are replaced with Lys and Phe respectively. Acts as a highly specific, potent inhibitor of calmodulin-dependent protein kinase II (CaMKII; IC50 = 4.1 nM). Displays ~10-fold greater potency than AIP. Inhibits PKC at higher concentrations (IC50 = 1 µM) and does not affect the activities of CaMK IV and PKA (IC50 > 100 µM). Purity: ≥97% by HPLC. H-Lys-Lys-Lys-Leu-Arg-Arg-Gln-Glu-Ala-Phe-Asp-Ala-Leu-OH Ref.: Ishida, A., et al. 1998. FEBS Lett. 427, 115. | 
