trans-1,4-bis(2-Chlorobenzylaminomethyl)cyclohexane, 2HCl
Shh Signaling Antagonist IV White solid. HYGROSCOPIC. PACKAGED UNDER INERT GAS. A cell-permeable amphiphilic diamine that blocks cholesterol biosynthesis and its esterification. Specifically blocks 7-dehydrocholesterol reductase (D7-sterol reductase) activity with IC50= 13 nM. Important tool in Sonic Hedgehog signaling and teratogenicity studies. Also reported to induce a rapid and irreversible reduction in Acidic-Sphingomyelinase activity in fibroblasts. Purity: ≥95% by HPLC. RTECS GU7025000, CAS 366-93-8. Ref.: Gofflot, F., et al. 2001. Dev. Dyn. 220, 99. Cooper, M.K., et al. 1998. Science 280, 1603. Incardona, J.P., et al. 1998. Development 125, 3553. Moebius, F.F., et al. 1998. Proc. Natl. Acad. Sci. USA95, 1899. Yoshida, Y. 1985. J. Biochem. 98, 1669. Kraml, M., et al. 1964. Biochem. Biophys. Res. Commun. 15, 455. |
