Aza-epoC Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A cell-permeable, lactam-based deoxyepothilone A analog that promotes tubulin polymerization in vitro. Reported to inhibit proliferation in KB-31 (IC50 = 464 nM) and KB-8511 (IC50 = 285 nM) human cancer cell lines. Exhibits improved metabolic stability and enhanced solubility. Purity: ≥95% by NMR. Ref.: Borzilleri, R.M., et al. 2000. J. Am. Chem. Soc. 122, 8890. Schinzer, D., et al. 2000. Chembiochem 1, 67. |
