AZT

White crystalline. PROTECT FROM LIGHT. Inhibitor of HIV-1 reverse transcriptase that blocks the incorporation of nucleotides into growing DNA strands. Useful for antiviral and anticancer studies. Enters CNS by diffusion and causes irreversible telomere shortening. Purity: >99% by HPLC. RTECS XP2072000, CAS 30516-87-1.

Merck Index: 14, 10123
Ref.: Gomez, D.E., et al. 1998. Biochem. Biophys. Res. Commun. 246, 107. Agarwal, R.P., and Olivero, O.A. 1997. Mut. Res. 390, 223. Thomas, S.A., and Segal, M.B. 1997. J. Pharmacol. Exp. Ther. 281, 1211. Strahl, C., and Blackburn, E.H. 1996. Mol. Cell. Biol. 16, 53. Yegorov, Y.E., et al. 1996. FEBS Lett. 389, 115.
R: 23/24/25; S: 36-45