Anti-b-Site Amyloid Precursor Protein (APP)-Cleaving Enzyme
Anti-b-Secretase

Host: Rabbit

Isotype: IgG

Immunogen: a synthetic peptide [(C)RQQHDDFADDISLLK] corresponding to amino acids 487-501 of human BACE

Form: Liquid

Formulation: Undiluted serum.

Preservative: None

Comments: Recognizes the ~65 and the ~75 kDa glycosylated forms of BACE in CHO cells transfected with BACE cDNA. Recognizes the ~50 kDa deglycosylated BACE protein after treatment with endoglycosidase F. Recognizes corresponding endogenous BACE in untransfected HEK293, SKNSH, and CHO cells.

Ref.: Pinnix, I., et al. 2001. FASEB J. 15, 1810. Bennett, B.D., et al. 2000. J. Biol. Chem. 275, 37712. Capell, A., et al. 2000. J. Biol. Chem. 275, 30849. Lin X., et al. 2000. Proc. Natl. Acad. Sci. USA 97, 1456. Vassar, R., et al. 1999. Science 286, 735. Yan, R., et al. 1999. Nature 402, 533.