1,2-bis(o-Aminophenoxy)ethane-N,N,N′,N′-tetraacetic Acid Tetra(acetoxymethyl) Ester Light yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Membrane-permeable form of BAPTA. Can be loaded into a wide variety of cells, where it is hydrolyzed by cytosolic esterases and is trapped intracellularly as the active chelator BAPTA. Prevents cocaine-induced ventricular fibrillations. Abolishes vitamin D3-induced increase in intracellular Ca2+. Induces inactivation of protein kinase C. Also inhibits thapsigargin-induced apoptosis in rat thymocytes. Purity: ≥90% by TLC. CAS 126150-97-8. Ref.: Bissonnette, M., et al. 1994. Am. J. Physiol. 267, G465. Jiang, S., et al. 1994. Exp. Cell Res. 212, 84. Billman, G.E. 1993. Am. J. Physiol. 265, H1529. Dieter, P., et al. 1993. Biol. Chem. Hoppe Seyler 374, 171. Harrison, S.M., and Bers, D.M. 1987. Biochim. Biophys. Acta 925, 133. Harrison, S.M., and Bers, D.M. 1987. J. Biophys. 51, 102A. Marban, E., et al. 1986. J. Clin. Invest. 78, 1185. Tsien, R.Y. 1981. Nature 290, 527. Tsien, R.Y. 1980. Biochemistry 19, 2396.
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