(E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile Off-white solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-a-inducible phosphorylation of IkBa (IC50 = 10 µM), resulting in a decreased expression of NF-kB and of adhesion molecules. Does not affect constitutive IkBa autophosphorylation. Inhibits TNF-a-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. Purity: ≥95% by HPLC. CAS 19542-67-7. Ref.: Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356. Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482. Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096. |
