1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2′-(trifluoromethyl)phenyl]-3-pyridinecarboxylic Acid Methyl Ester Yellow solid. PROTECT FROM LIGHT. Synthetic dihydropyridine derivative that acts as an active Ca2+ slow channel agonist in neuroendocrine, muscle, thyroid and other cell types. Prolongs single channel open time without affecting the close time. An L-type Ca2+ channel agonist. Composed of two optical isomers. The (-)-enantiomer has strong vasoconstrictive, positive inotropic, and Ca2+ agonistic properties, whereas the (+)-enantiomer has weakly vasodilating, negative inotropic, and Ca2+ antagonistic properties. The net effect of the racemic mix is that of the negative enantiomer. Purity: ≥98% by HPLC. CAS 93468-89-4. Ref.: Weigl, L.G., et al. 2000. J. Physiol. 525 (pt. 2), 461. Vannier, C., et al. 1995. Am. J. Physiol. 268, L201. Bechem, M., and Hoffmann, H. 1993. Pflugers Arch. 424, 343. Triggle, D.J., and Rompe, D. 1989. Trends Pharmacol. Sci. 10, 507. Takasu, N., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1107. Tagliatela, M., et al. 1986. Brain Res. 381, 356. Franckowiak, G., et al. 1985. Eur. J. Pharmacol. 114, 223.
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