B Cell Lymphoma 10
c-CARMEN
CIPER
CLAP
c-E10
mE10

Liquid. In 100 mM KCl, 20 mM Tris-HCl, 10 mM b-mercaptoethanol, 0.2 mM EDTA, 20% glycerol, pH 7.9. AVOID FREEZE/THAW CYCLES. Recombinant, human Bcl-10 expressed in S. frugiperda insect cells using a baculovirus expression system. Bcl-10 is an apoptotic regulatory molecule identified through its direct involvement in t(1;14)(p22;q32) of mucosa-associated lymphoid tissue (MALT) lymphomas. The human bcl-10 gene encodes a protein of 233 amino acids containing an N-terminal caspase recruitment domain (CARD) characteristic of both proapoptotic and antiapoptotic molecules. Bcl-10 is expressed ubiquitously with high expression levels in lymphoid tissues and in the developing central nervous system. Forced expression of wild type Bcl-10 in cell lines induces apoptosis and activates NF-kB. Bcl-10-initiated NF-kB can be inhibited by cotransfection of dominant-negative mutants of TRAF2, NIK, IKKa, or IkBa. Activity: 1 unit/ng protein. 100 units are sufficient for protein-protein interaction assays.. Purity: ≥95% by SDS-PAGE.

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