2-[1-(3-Dimethylaminopropyl)-1H-indol-3-yl]-3-(1H-indol-3-yl)maleimide, HCl Orange-red solid. An enhanced water-soluble form of Bisindolylmaleimide I (Cat. No. 203290). Inhibits protein kinase C (Ki = 10 nM). May inhibit protein kinase A at much higher concentrations (Ki = 2 µM). Purity: ≥95% by HPLC. CAS 176504-36-2. Ref.: Le Panse, R., et al. 1994. Mol. Pharmacol. 46, 445. Kuchera, S., et al. 1993. Agents Actions 39, C169. Wilkinson, S.E., et al. 1993. Biochem. J. 294, 335. Toullec, D., et al. 1991. J. Biol. Chem. 266, 15771.
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