Blue lyophilized solid. PROTECT FROM LIGHT. HYGROSCOPIC. A unique antibiotic of the bleomycin family that is toxic to eukaryotic and prokaryotic cells. BLEOCIN™ Antibiotic cleaves double-stranded DNA and inhibits DNA synthesis, resulting in cell death. Can be used for selection of recombinant clones in a variety of cell types transfected with vectors containing a ble resistance marker. Copper content: ≥3.5%. Potency: ≥750 µg/mg. Purity: ≥85% by HPLC. RTECS EC5990700, CAS 55658-47-4.

Ref.: Sergeev, D.S., et al. 1995. Bioorg. Khim. 21, 695. Mulsant, P., et al. 1988. Somatic Cell and Molecular Genetics 14, 243. Ehrenfeld, G.M., et al. 1987. Biochemistry 26, 931. Takita, T., et al. 1972. J. Antibiot. 25, 755.
R: 20/21/22-36/37/38-40-42/43; S: 22-26-36/37/39-45