BA, 3NH4
3-Carboxymethyl-17-methoxy-6,18,21-trimethyldocosa-2,4,8,12,18,20-heptaenedioic Acid Off-white lyophilized solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. Acts as a ligand of the adenine nucleotide translocator. A potent inhibitor of mitochondrial megachannel (permeability transition pore). Significantly reduces signs of apoptosis induced by nitric oxide. Prevents the apoptotic breakdown of the inner mitochondrial transmembrane potential (DYm), as well as a number of other phenomena linked to apoptosis. Purity: ≥92% by HPLC. Merck Index: 14, 1332
Ref.: Hirsch, T., et al. 1998. J. Immunol. 161, 35. Horteleno, S., et al. 1997. FEBS Lett. 410, 373. Marchetti, P., et al. 1996. J. Exp. Med. 184, 1155. Marchetti, P., et al. 1996. J. Immunol. 157, 4830. Zamzami, N., et al. 1996. J. Exp. Med. 183, 1533. Henderson, P.J., and Lardy, H.A. 1970. J. Biol. Chem. 245, 1319.
R: 20/21/22-40; S: 36-22 |
