Protein Kinase G Substrate
RKISASEFDRPLR Lyophilized. Supplied as a trifluoroacetate salt. HYGROSCOPIC. Sequence derived from bovine lung cGMP-specific phosphodiesterase (cG-BPDE). A specific and sensitive substrate for PKG (Km = 68 µM) relative to PKA (Km = 320 µM). Not phosphorylated by PKC or by CaM kinase II. Purity: ≥95% by HPLC. Sold on the basis of peptide content. H-Arg-Lys-Ile-Ser-Ala-Ser-Glu-Phe-Asp-Arg-Pro-Leu-Arg-OH Ref.: Gertzberg, N., et al. 2000. Am. J. Respir. Cell Mol. Biol. 22, 105. Patel, A.I., and Diamond, J. 1997. J. Pharmacol. Exp. Ther. 283, 885. Colbran, J.L., et al. 1992. J. Biol. Chem. 267, 9589. Corbin, J.D., and Døskeland, S.O. 1983. J. Biol. Chem. 258, 11391. |
