Potassium Bisperoxo(1,10-phenanthroline)oxovanadate (V) Yellow solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent protein phosphotyrosine phosphatase inhibitor and insulin receptor kinase (IRK) activator. Excellent insulin mimetic at 15 µg/kg in vitro and in vivo for use. Inhibits the in situ dephosphorylation of autophosphorylated insulin receptors with over 1000-fold greater potency than sodium orthovanadate. Arrests proliferation of neuroblastoma NB 41 and glioma C6 cells at the G2/M transition of the cell cycle. Also reported to potently inhibit PTEN (IC50 = 38 nM). Purity: ≥99% by 51V-NMR. Ref.: Schmid, A.C., et al. 2004. FEBS Lett. 566, 35. Muzyamba, M.C., et al. 1999. J. Physiol. 517, 421. Drake, P.G., et al. 1996. Endocrinology 137, 4960. Bevan, A.P., et al. 1995. Am. J. Physiol. 268, E60. Bevan, A.P., et al. 1995. J. Biol. Chem. 270, 10784. Yale, J.F., et al. 1995. Diabetes 44, 1274. Posner, B.I., et al. 1994. J. Biol. Chem. 269, 4596. |
