Bryo 2 Colorless solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A macrocyclic lactone with antitumor properties. Competes with phorbol ester binding to protein kinase C (PKC) (Kc=3.4 nM) and antagonizes phorbol ester action. Also exhibits growth inhibitory activity against several human cancer cell lines (GI50= 1.8-170 ng/ml). Purity: ≥98% by TLC. CAS 87745-28-6. Ref.: Wender, P.A., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 6624. Dale, I.L., et al. 1989. Cancer Res. 49, 3242. |
