N-Benzyl-p-toluenesulphonamide White crystalline solid. PROTECT FROM LIGHT. PACKAGED UNDER INERT GAS. A potent inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 ~5 µM) and reversibly blocks the gliding motility. It also weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II. Purity: ≥95% by HPLC. RTECS XT5490000, CAS 1576-37-0. Ref.: Cheung, A., et al. 2002. Nat. Cell Biol. 4, 83. |