BDM Off-white solid. HYGROSCOPIC. An inhibitor of skeletal and cardiac muscle contraction. A general reversible inhibitor of myosin ATPase in eukaryotes. A “chemical phosphatase,” which dephosphorylates acetylcholinesterase poisoned with organophosphates. Inhibits Ca2+ currents in adult rat cervical ganglion in a reversible and dose-dependent manner (IC50 = 18.3 nM). Also shown to induce Ca2+ release from canine cardiac sarcoplasmic reticulum (SR). Purity: ≥98% by GC. RTECS EK3150000, CAS 57-71-6. Ref.: Phillips, R.M., and Altschuld, R.A. 1996. Biochem. Biophys. Res. Commun. 229, 154. Sellin, L.C., and McArdle, J.J. 1994. Pharmacol. Toxicol. 74, 305. Zhu, Y., and Ikeda, S.R. 1993. Neurosci. Lett. 155, 24. |
