2-Chloro-2′-arabinofluoro-2′-deoxyadenosine

White solid. A lipophilic and more acid stable derivative of 2-Chloro-2′-deoxyadenosine (CdA; Cat. No. 220467). A better substrate than CdA for deoxycytidine kinase (dCK), the key enzyme in the activation of nucleoside analogues. Inhibits the growth of human K562 cells by blocking both ribonucleotide reduction and DNA polymerization. CAFdA is toxic to non-dividing lymphocytes and monocytes at nanomolar concentrations. Also induces apoptosis in leukemia cells. Purity: ≥97% by HPLC. RTECS UD7473000, CAS 123318-82-1.

Ref.: Genini, D., et al. 2000. Blood 96, 3537. Lindemalm, S., et al. 1999. Med. Oncol. 16, 239. Lotfi, K., et al. 1999. Clin. Cancer Res. 5, 2438. Lindemalm, S., et al. 1997. Anticancer Drugs 8, 445. Carson, D.A., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2970. Parker, W.B., et al. 1991. Cancer Res. 51, 2386.
R: 20/21/22-36/37/38-40; S: 26-36